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GR abolished the formation of enteric neural networks. In the small intestine in H-line: Thy1 promoter green fluorescent protein (GFP) mice, we obtained clear 3-dimensional imaging of enteric neurons that were newly generated by oral application of MOS after gut transection and anastomosis.All findings indicate that treatment with 5-HT Brain-derived neurotrophic factor (BDNF) applied locally at the anastomosis promoted regeneration of the distal gut reflex pathways in the enteric nervous system (ENS) and repaired the anal dysfunction.However, neuroepithelial stem cells (NESCs) harvested from the neural tube of embryonic rats can differentiate into NCSCs, which in turn generate peripheral nervous system derivatives.NESCs have a very broad developmental capacity and may generate a multiple of cell types and thus NESCs transplanted into the surviving denervated colon could differentiate into neurons and glial cells in vivo.
exhibit aganglionic megacolon, Hirschsprung disease. Neural crest stem cells (NCSCs) never migrate into the aganglionic portion of the gut in animals affected by RET or EDNRB deficiency, despite the presence of NCSCs in region of the foregut and mid-gut that are colonized by NC.
BDNF, however, has serious detrimental actions such as pro-inflammatory action on the anastomosis and thus we explored a small molecule candidate promoting enteric neurogenesis.
We found a brief report showing that some 5-hydroxytryptamine 4 receptor (5-HT Takaki directed her attention to restoration of functional recto-anal inhibitory reflex connections and defecation following resection and anastomosis in a guinea pig model and published the first evidence that serotonergic action at the 5-HTThe gut contains a large 5-HT pool in EC cells and a smaller 5-HT pool in the ENS.
The ENS originates from the NC, mostly from the vagal levels of the neuraxis, which invades, proliferates, and migrates within the intestinal wall until the entire bowel is colonized with ENCDCs.
After initial migration, the ENS develops further by responding to guidance factors and morphogens that pattern the bowel concentrically, differentiating into glia and neuronal subtypes and wiring together to form a functional nervous system.
However, sciatic nerve NCSCs failed to migrate into the gut or to make enteric neurons, even when transplanted into the gut wall.